代表性研究论文

方向一：

1.       Shengtao Li, Tiantian Lu, Xinxin Xu, Yi Ding, Zijie Li, Toshihiko Kitajima, Neta Dean, Ning Wang, Xiao-Dong Gao. Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans. Nature Communications. 2019, 10: 1813. 

2.       Shini Feng, Huijie Zhang, Sha Xu, Chunyi Zhi, Hideki Nakanishi, Xiao-Dong Gao.  Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin. Materials Science & Engineering C-Materials for Biological Applications. 2019, 96: 552-560.  Xinxin Xu, ShengtaoLi, Ning Wang, Toshihiko Kitajima, Takehiko Yoko-o, Morihisa Fujita, Hideki Nakanishi, Xiao-Dong Gao. Structural and functional analysis of Alg1 beta-1,4 mannosyltransferase reveals the physiological importance of its membrane topology. Glycobiology. 2019, 28(10): 741-753. 

3.       Aimin Li, Shenglin Duan, Yanting Dang, Xi Zhang, Kai Xia, Shiwei Liu, Xiaofeng Han, Jian Wen, Zijie Li, Xi Wang, Jia Liu, Peng Yuan, Xiao-Dong Gao. Origin identification of Chinese Maca using electronic nose coupled with GC-MS. Scientific Reports. 2019, 9: 12216.   

4.       Shenbao Zhao, Yasuyuki Suda, Hideki Nakanishi, Ning Wang, Takehiko Yoko-o, Xiao-Dong Gao, Morihisa Fujita. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network. Biochimica et Biophysica Acta-General Subjects. 2019, 1863(6): 1147-1157. 

5.       Kankai Shao, Qin Wang, Ning Wang, Xiao-Dong Gao, Hideki Nakanishi. Construction of functional chimeras of syntaxin-1A and its yeast orthologue, and their application to the yeast cell -based assay for botulinum neurotoxin serotype C. Biochimica et Biophysica Acta-General Subjects. 2019, 1863(11): UNSP 129396.  

6.       Xiaoxiao Liu, Zijie Li, Zhou Chen, Ning Wang, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao. Production of L-Ribulose Using an Encapsulated L-Arabinose Isomerase in Yeast Spores. Journal of Agricultural and Food Chemistry. 2019, 67(17): 4868-4875.       

7.         Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou, Guiyang Shi. Production of L-tyrosine using tyrosine phenol-lyase by whole cell biotransformation approach. Enzyme and Microbial Technology. 2019, 131, 109430. 

8.       Weiwei Ren, Zecheng Jin, Weijie Dong, Kitajima T, Xiao-Dong Gao, Fujita Morihisa. Glycoengineering of HEK293 cells to produce high-mannose-type N-glycan structures. Jounal of Biochemistry. 2019, 166(3): 245-258.

9.      Osei Mensah Emmanuel, XinYu Guo, Xiao-Dong Gao, Morihisa Fujita. Establishment of DHFR-deficient HEK293 cells for high yield of therapeutic glycoproteins. Journal of Bioscience and Bioengineering. 2019, 128(4): 487-494. 

10.  Fujita Morihisa. Structural Remodeling and Shedding of GPI-Anchors. Trends in Glycoscience and Glycotechnology. 2019, 181(31): SE71-SE73. 

方向二

11.     Haofei Hong, Zhifang Zhou, Kun Zhou, Shaozhong Liu，Zhongwu Guo, Zhimeng Wu. Site-specific C-terminal dinitrophenylation to reconstitute the antibody Fc functions for nanobodies. Chemical Science. 2019,10, 9331-9338. 

12.   Tingting Meng, Jing Han, Pengfei Zhang, Jing Hu, Junjie Fu, Jian Yin. Introduction of the alpha-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs. Chemical Science. 2019, 10(30): 7156-7162. 

13.   Jia Li, Wenhao Bao, Zhaocheng Tang, Baodang Guo, Shiwei Zhang, Haili Liu, Shuping Huang, Yan Zhang, Yijian Rao. Cercosporin-Bioinspired Selective Photooxidation Reactions under Mild Conditions. Green Chemistry. 2019, 21, 6073-6081.  

14.   Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou, Jinghua Chen. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nano-particles for Liver Cancer Therapy. Applied Materials Today. 2019, doi.org/10.1016/j.apmt.2019.100521  IF8.013

15.   Zhaocheng Tang, Jia Li, Fulin Lin, Wenhao Bao, Shiwei Zhang, Baodang Guo, Shuping Huang, Yan Zhang, Yijian Rao. Cercosporin-bioinspired photoreductive activation of aryl halides under mild conditions. Journal of Catalysis. 2019, 380: 1-8.  

16.   Shuqin Xu, Shuyu Zhou, Baoliang Mao, Jinghua Chen, Ziyin Zhang. Cornea-stroma-mimicking films derived from cellulose nanocrystal templating fibrous collagen as therapeutic contact lenses. ACS Sustainable Chemistry Engineering. 2019, 7 (14): 12248-12260.  

17.   Junjie Fu, Jing Han, Tingting Meng, Jing Hu, Jian Yin. Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity. Chemical Communications. 2019, 55(86): 12904-12907. 

18.     Sha Zhu, Xiaoying Wang, Cheng Jing, Yongmei Yin, Nandi Zhou. A colorimetric ATP assay based on the use of a magnesium(II)-dependent DNAzyme. Microchimica Acta. 2019, 186: 176.

19.     Rongfeng Cai, Fan Yin, Zhongwen Zhang, Yaping Tian, and Nandi Zhou. Functional chimera aptamer and molecular beacon based fluorescent detection of Staphylococcus aureus with strand displacement-target recycling amplification. Analytica Chimica Acta. 2019, 1075: 128-136. 

20.  Yaling Wu, Zheng Xu, Wenjing Sun, Yingyue Yang, Hui Jin, Lipeng Qiu, Jinghua Chen, and Jingxiao Chen. Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment. Materials Science & Engineering C. 2019, 103: 109831.  

21.  Huiyan Ying, Juan Zhou, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv and Jinghua Chen. In Situ Formed Collagen-Hyaluronic Acid Hydrogel as Biomimetic Dressing for Promoting Spontaneous Wound Healing. Materials Science and Engineering: C. 2019, 101: 487-498. 

22.   Kamel S. Ahmed, Xiaotian Shan, Jing Mao, Lipeng Qiu, Jinghua Chen. Derma roller microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect. Materials Science & Engineering C. 2019, 99: 1448-1458.  

23.   Liang-Hua Zou, Hao Zhu, Shuai Zhu, Kai Shi, Cheng Yan, and Ping-Gui Li. Copper-Catalyzed Ring-Opening/Reconstruction of Anthranils with Oxo-Compounds: Synthesis of Quinoline Derivatives. Journal of Organic Chemistry. 2019, 84: 12301-12313.

24.  Dandan Su, Juan Zhou, Kamel S.Ahmed, Qiaoqiao Ma, Guozhong Lv, Jinghua Chen. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold. International Journal of Biological Macromolecules. 2019, 129: 895-903.

25.   Shuqin Xu, Meiling Qiu, Quan Zhang, Jing Wu, Xiang Huimin, Jinghua Chen. Chain structure and immunomodulatory activity of fructosylated chondroitin from an engineered Escherichia coli K4. International Journal of Biological Macromolecules. 2019, 133: 702-711.

26.   Yaling Wang, Xingming Ji, Meilin Yan, Xue Chen, Mingzhu Kang, Liping Teng, Xiaotao Wu, Jinghua Chen, Chao Deng. Protective effect and mechanism of polysacchardie from Dictyophora indusiata on dextran sodium sulfate-induced colitis C57BL/6 mice. International Journal of Biological Macromolecules. 2019, 140: 973-984. 

27.   Yaling Wang, Li Lai, Liping Teng, Yuhong Li, Jiangqing Cheng, Jinghua Chen, Chao Deng. Mechanism of the anti-inflammatory activity by a polysaccharide from Dictyophora indusiata in lipopolysaccharide-stimulated macrophages. International Journal of Biological Macromolecules. 2019, 126: 1158-1166. 

28.   Yan Zhang, Yuan Cao, Liushen Lu, Shiwei Zhang, Wenhao Bao, Shuping Huang, Yijian Rao. Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives . Journal of Organic Chemistry. 2019, 84(12): 7711-7721. 

29.    Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen. Silk fibroin for CpG oligodeoxynucleotides delivery. ACS Biomaterials Science & Engineering. 2019, DOI: 10.1021/acsbiomaterials.9b01413.    

30.  Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lv and Jinghua Chen. Extracellular Matrix Component Shelled Nanoparticles as Dual Enzyme-Responsive Drug Delivery Vehicles for Cancer Therapy. ACS Biomaterials Science & Engineering. 2018, 4: 2404-2411.

31.  Safia Naz, Mingyu Wang, Yuning Han, Bin Hu, Liping Teng, Juan Zhou, Huijie Zhang and Jinghua Chen. Enzyme Responsive Mesoporous Silica Nanoparticles for Tumor Cells and Mitochondria Multistage-Targeted Drug Delivery. International Journal of Nanomedicine. 2019, 13: 2533-2542.  

32.  Safia Naz, Muhammad Shamoon, Rui Wang, Li Zhang, Juan Zhou, Jinghua Chen. Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer. International Journal of Molecular Science. 2019, 20, 965-982. 

33.     Binbin Yao, Sha Zhu, Xinyu Xu, Ninghan Feng, Yaping Tian, Nandi Zhou. Ultrasensitive detection of the androgen receptor through the recognition of an androgen receptor response element and hybridization chain amplification. Analyst. 2019, 144: 2179-2185. 

34.     Kai Zhao, Feng Tang, Wei Shi, Haofei Hong, Zhifang Zhou, Wei Huang, Zhimeng Wu. One-step immobilization and purification of genetic engineering CBD fusion EndoS on cellulose for antibodies Fc-glycan remodeling. Bioorganic Chemistry. 2019, 91.       

35.   Shiwei Zhang, Zhaocheng Tang, Wenhao Bao, Jia Li, Baodang Guo, Shuping Huang, Yan Zhang, Yijian Rao. Perylenequinonoid-catalyzed photoredox activation for the direct arylation of (het)arenes with sunlight Electronic supplementary information (ESI) available. Organic & Biomolecular Chemistry. 2019, 17(17):4364-4369.  

36.   Jia Li, Wenhao Bao, Yan Zhang, Yijian Rao. Cercosporin-photocatalyzed sp3 (C-H) Activation for the Synthesis of Pyrrolo[3,4-c]quinolones. Organic & Biomolecular Chemistry. 2019, 17(40): 8958-8962.  

37.   Ping-Gui Li, Hao Zhu, Min Fan, Cheng Yan, Kai Shi, Xi-Wen Chi, Liang-Hua Zou. Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides. Organic and Biomolecular Chem.istry. 2019, 17: 5902-5907.

38.   Shengtao Wang, Jingtao Li, Zhou Ye, Jieling Li, Anhe Wang, Jing Hu, Shuo Bai, Jian Yin. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019, 574: 44-51. 

39.   Zhou Ye, Dong Hua, Yijian Rao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer. Colloids and Surfaces A: Physicochemical and Engineering Aspects. doi.org/10.1016/j.colsurfa.2019.124136. 

40.   Di Wang, Meiyue Wang, Anhe Wang, Jieling Li, Xin Li, Honglei Jian, Shuo Bai, Jian Yin. Preparation of collagen/chitosan microspheres for 3D macrophage proliferation in vitro. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019, 572: 266-273. 

41.   Ahmed Kamel S，Hussein Saied A，Ali Abdelmoneim H，Korma Sameh A, Lipeng Qiu, Jinghua Chen. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications. Journal of Drug Targeting. 2019, 27(7): 742-761. 

42.   Jia Li, Wen-Hao Bao, Yan Zhang, Yijian Rao. Cercosporin-photocatalyzed C-S Coupling for the Selective Synthesis of Aryl Sulfides under Mild Conditions. European Journal of Organic Chemistry. 2019, DOI: 10.1002/ejoc.201901444. 

43.   Yijun Wang, Shuai Zhu, Liang-Hua Zou. Recent Advances in Direct Functionalization of Quinones. European Journal of Organic Chemistry. 2019, 2179-2201.

44.   Liang-Hua Zou, Cheng Yan, Kai Shi,Liang Su, Shuai Zhu, Zhe-Kang Jia, and Qiuan Wang. Copper-Catalyzed C–C Bond Cleavage/Double Cyclization of α-Ketoamides with o-Phenylene Diamines: Synthesis of Benzimidazo[1,2-c]quinazolin-6-ones. European Journal of Organic Chemistry. 2019, DOI: 10.1002/ejoc.201901642.

45.   Haofei Hong, Xinrui Zhao, Zhimeng Wu. A two-stage glycine supplementation strategy enhances the extracellular expression of Sortase A in Escherichia coli. Process Biochemistry. 2019, 76, 11-17. 

46.     Ying Ou, Xin Jin, Jing Liu, Yaping Tian, Nandi Zhou. Visual detection of kanamycin with DNA-functionalized gold nanoparticles probe in aptamer-based strip biosensor. Analytical Biochemistry. 2019, 587: 113432.

47.   Xiaotian Shan, Jing Mao, Miaomiao Long, Kamel S. Ahmed, Changling Sun, Lipeng Qiu, Jinghua Chen. Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle. Applied Polymer. 2019, 136(32): 47854-47861. 

48.   Xiaopeng Zou, Chunjun Qin, Jing Hu, Junjie Fu, Guangzong Tian, Oren Moscovitz, Peter H.Seeberger, Jian Yin. Total Synthesis of _D-Glycero-_D-mannno-heptose 1β,7-Bisphosphate with 3-O-Amyl Amine Linker and Its Monophosphate Derivative. Chinese Journal of Natural Medicines. Accepted.  

49.   Jing Hu, Yong Xiao, Shu'an Shao, Rui Gu, Qimin Shi, Zhonghua Liu, Jian Yin. Construction and application of carbohydrate microarrays to detect foodborne bacteria. Chinese Journal of Natural Medicines. Accepted 

50.   Chen Li, Shijie Dai, Aijie Cao, Zhifang Zhou, Zhimeng Wu. Design and synthesis of rhamnose-modified exenatide conjugate by sortase A-mediated ligation. Journal of Carbohydrate Chemistry. 2019, 38(3): 167-178. 

51.   Qingquan Han, Yang Chen, Wei Song, Milin Zhang, Shengtao Wang, Peng Ren, Linna Hao, Anhe Wang, Shuo Bai, Jian Yin. Fabrication of agarose hydrogel with patterned silver nanowires for motion sensor. Bio-Design and Manufacturing. 2019, doi.org/10.1007/s42242-019-00051-w.  

方向三

52.   Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Synthetic Biology Toolbox and Chassis Development in Bacillus subtilis. Trends in Biotechnology. 2019, 37(5): 548-562.  

53.   Xiaolong Zhang, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Microbial production of sialic acid and sialylated human milk oligosaccharides: Advances and perspectives. Biotechnology Advances. 2019, 37: 787-900.

54.   Yaokang Wu, Taichi Chen, Yanfeng Liu, Rongzhen Tian, Xueqin Lv, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in Bacillus subtilis. Nucleic Acids Research. 2019, Accepeted. 

55.   Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis. Metabolic Engineering. 2019, 51: 59-69. 

56.   Jieying Deng, Chunmei Chen, Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Rodrigo Ledesma-Amaro, Guocheng Du, Long Liu. Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis. Metabolic Engineering. 2019, 55: 179-190.  

57.   Rongzhen Tian, Yanfeng Liu, Chen, JR; Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Synthetic N-terminal coding sequences for fine-tuning gene expression and metabolic engineering in Bacillus subtilis. Metabolic Engineering. 2019, 55: 131-141.

58.   Hao Wang, Lin Zhang, Weijiao Zhang, Yang Wang, Jianghua Li, Guocheng Du, Zhen Kang. Secretory expression of biologically active chondroitinase ABC I for production of chondroitin sulfate oligosaccharides. Carbohydrate Polymers. 2019, 224, 115135.      

59.   Shixiu Cui, Xueqin Lv, Yaokang Wu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Engineering a Bifunctional Phr60-Rap60-Spo0A Quorum-Sensing Molecular Switch for Dynamic Fine-Tuning of Menaquinone-7 Synthesis in Bacillus subtilis. ACS Synthetic Biology. 2019, 8: 1826-1837.  

60.   Jieying Deng, Liuyan Gu, Taichi Chen, Hao Huang, Xiaoqiang Yin, Xueqin Lv, Yanfeng Liu, Nan Li, Zhenmin Liu, Jianghua Li, Guocheng Du, Long Liu. Engineering the Substrate Transport and Cofactor Regeneration Systems for Enhancing 2′-Fucosyllactose Synthesis in Bacillus subtilis. ACS Synthetic Biology. 2019, 8: 2418-2427.  

61.   Xiaomin Dong, Nan Li, Zhenmin Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Miao Wang, Long Liu. Modular pathway engineering of key precursor supply pathways for lacto‑N‑neotetraose production in Bacillus subtilis. Biotechnology for Biofuels. 2019, 12: 212. 

62.   Wenlong Ma, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Combinatorial pathway enzyme engineering and host engineering overcomes pyruvate overflow and enhances overproduction of N-acetylglucosamine in Bacillus subtilis. Microbial Cell Factories. 2019, 18: 1. 

63.   Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells. Biotechnology and Bioengineering. 2019, 116: 5-18.  

64.   Jiang, Z; Tengfei Niu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Lu, W; Guocheng Du, Jian Chen, Long Liu. Secretory Expression Fine-Tuning and Directed Evolution of Diacetylchitobiose Deacetylase by Bacillus subtilis. Applied and Environmental Microbiology. 2019, 85(17): e01076-19.  

65.  Haiquan Yang, Jinyuan Hu, Xiao Lu, Fuxiang Wang, Wei Shen, Wei Hu, Lingling Wang, Xianzhong Chen, Long Liu. Improving extracellular protein production in Escherichia coli by overexpressing D,D-carboxypeptidase to perturb peptidoglycan network synthesis and structure. Applied Microbiology and Biotechnology. 2019, 103(2): 793-806. 

66.   Wei Hu, Wenjian Li, Haiquan Yang, Jihong Chen. Current strategies and future prospects for enhancing microbial production of citric acid. Applied Microbiology and Biotechnology. 2019, 103(1): 201-209.   

67.  Haiquan Yang, Yuxiang Xue, Cui Yang, Wei Shen, You Fan, and Xianzhong Chen. Modular engineering of tyrosol production in Escherichia coli. Journal of Agricultural and Food Chemistry. 2019, 67: 3900-3908. 

68.   Yang Wang, Qingtao Liu, Huanjiao Weng, Shi, YA; Jian Chen, Guocheng Du, Zhen Kang. Construction of Synthetic Promoters by Assembling the Sigma Factor Binding-35 and-10 Boxes. Biotechnology Journal. 2019, 14, 1800298. 

69.   Lin Zhao, Rongzhen Tian, Qingyang Shen, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du. Pathway Engineering of Bacillus subtilis for Enhanced N-Acetylneuraminic Acid Production via Whole-Cell Biocatalysis. Biotechnology Journal. 2019, 14, 1800682.  

70.   Mengyan Pan, Jianghua Li, Xueqin Lv, Guocheng Du, Long Liu. Molecular engineering of chitinase from Bacillus sp. DAU101 for enzymatic production of chitooligosaccharides. Enzyme and Microbial Technology. 2019, 124: 54-62.  

71.  Haiquan Yang, Fuxiang Wang, Haokun Wang, Xiao Lu, Wei Shen, Xianzhong Chen. Deleting mrdA and mrcB to significantly improve extracellular recombinant protein production in Escherichia coli. Biochemical Engineering Journal. 2019, 143: 185-195. 

72.   Qingtao Liu, Xuerong Jin, Fang Fang, Jianghua Li, Guocheng Du, Zhen Kang. Food-grade expression of an iron-containing acid urease in Bacillus subtilis. Journal of Biotechnology. 2019, 293: 66-71. 

73.   Yang Wang, Jian Chen, Zhen Kang. In Silico Protein Design Promotes the Rapid Evolution of Industrial Enzymes. Biochemistry. 2019, 58: 1451-1453. 

74.   Xing Zhou, Jing He, Li Wang, Yang Wang, Guocheng Du, Zhen Kang. Metabolic Engineering of Saccharomyces cerevisiae to Improve Glucan Biosynthesis. Journal of Microbiology and Biotechnology. 2019, 29(5): 758-764.  

75.   Haibo Yuan, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Zhongping Shi, Long Liu. Enhanced 2,5-Furandicarboxylic Acid (FDCA) Production in Raoultella ornithinolytica BF60 by Manipulation of the Key Genes in FDCA Biosynthesis Pathway. Journal of Microbiology and Biotechnology. 2019, 28 (12): 1999-2008.  

76.  Jinyuan Hu, Xiao Lu, Haokun Wang, Fuxiang Wang, Yuan Zhao, Wei Shen, Haiquan Yang, Xianzhong Chen. Enhancing extracellular protein production in Escherichia coli by deleting the D-alanyl-D-alanine carboxypeptidase gene dacC. Engineering in Life Sciences. 2019, 19(4): 246-327. 

77.   Zhengxiong Zhou, Qing Li, Ruirui Xu, Bingbing Wang, Guocheng Du, Zhen Kang. Secretory expression of the rat aryl sulfotransferases IV with improved catalytic efficiency by molecular engineering. 3 Biotech. 2019, 9: 246. 

78.   Nshimiyimana, P; Long Liu, Guocheng Du. Engineering of L-amino acid deaminases for the production of α-keto acids from L-amino acids. Bioengineered. 2019, 10(1): 43-51.      

79.   Yang Fan, Chen Liangqiang, Liu Yanfeng, Li Jianghua, Li Wang, Chen Jian. Identification of microorganisms producing lactic acid during solid-state fermentation of Maotai flavour liquor. Journal of the Institute of Brewing. 2019, 125(1): 171-177. 

80.   Chen Deng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Wei Lu, Guocheng Du, Long Liu. Metabolic engineering of Corynebacterium glutamicum S9114 based on whole-genome sequencing for efficient N-acetylglucosamine synthesis. Synthetic and Systems Biotechnology. 2019, 4: 120-129.  

方向四

81.   Bobo Zhang, Yuyan Guan, Pengfei Hu, Lei Chen, Ganrong Xu, Liming Liu, Peter C.K. Cheung. Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development. Critical Reviews in Biotechnology. 2019, 39: 541-554. 

82.  Lei Chen, Zhengqi Wang, Bobo Zhang, Mengdie Ge, Huisuan Ng, Yuge Niu, Liming Liu. Production, structure and morphology of exopolysaccharides yielded by submerged fermentation of Antrodia cinnamomea. Carbohydrate Polymers. 2019, 205: 271-278.     

83.   Lei Chen, Mengdie Ge, Yujie Zhu, Yu Song, Peter C. K. Cheung, Bobo Zhang, Liming Liu. Structure, bioactivity and applications of natural hyperbranched polysaccharides. Carbohydrate Polymers. 2019, 223: 115076.   

84.   Chang Su, Jinsong Gong, Yuxin Sun, Jiufu Qin, Shen Zhai, Heng Li, Hui Li,Zhenming Lu, Zhenghong Xu, Jinsong Shi. Combining Pro-peptide Engineering and Multisite Saturation Mutagenesis to Improve the Catalytic Potential of Keratinase. ACS Synthetic Biology. 2019, 8(2), 425-433. 

85.   Kangle Wang, Zhenming Lu, Xiangjunzhi Mao, Lu Chen, Jinsong Gong, Yilin Ren, Yan Geng, Heng Li, Hongyu Xu, Guohua Xu, Jinsong Shi, Zhenghong Xu. Structural Characterization and Anti-alcoholic Liver Injury Activity of A Polysaccharide from Coriolus versicolor mycelia. International Journal of Biological Macromolecules. 2019, 137: 1102-1111.  

86.   Xun-Cheng Zong, Chuang Li, Yao-Hui Xu, Die Hu, Bo-Chun Hu, Jia Zang and Min-Chen Wu. Substantially improving the enantioconvergence of PvEH1, a Phaseolus vulgaris epoxide hydrolase, towards m-chlorostyrene oxide by laboratory evolution. Microbial Cell Factories. 2019,18: 202.

87.   Chuang Li , Jun Zhao , Die Hu, Bo-Chun Hu, Rui Wang , Jia Zang , Min-Chen Wu. Multiple site-directed mutagenesis of a Phaseolus vulgaris epoxide hydrolase to improve its catalytic performance towards p-chlorostyrene oxide based on the computer-aided re-design. International Journal of Biological Macromolecules. 2019, 121: 326-332.

88.   Chuang Li, Bo-Chun Hu, Die Hu, Xiong-Feng Xu, Xun-Cheng Zong, Jin-Ping Li, Min-Chen Wu. Stereoselective ring-opening of styrene oxide at elevated concentration by Phaseolus vulgaris epoxide hydrolase, PvEH2, in the organic/aqueous biphasic system. Catalysis Communications. 2019, 123: 1-5.

89.  Yanjie Chunyu, Zhenming Lu, Zhishan Luo, Shuoshuo Li, Hui Li,Yan Geng, Hong-yu Xu, Zhenghong Xu, Jinsong Shi. Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae. Journal of Agricultural and Food Chemistry. 2019, 67(31): 8476-8484.

90.   Deqiang Zhu, Jianrong Wu, Xiaobei Zhan, Li Zhu, Yun Jiang. Enhanced N-acetyl-d-neuraminic production from glycerol and N-acetyl-_D-glucosamine by metabolically engineered Escherichia coli with a two-stage pH-shift control strategy. Journal of Industrial Microbiology & Biotechnology. 2019, 46(2): 125-132.

91.   Chuang Li, Ting-Ting Kan, Die Hu, Ting-Ting Wang, Yong-Jun Su, Chen Zhang, Jian-Qing Cheng, Min-Chen Wu. Improving the activity and enantioselectivity of PvEH1, a Phaseolus vulgaris epoxide hydrolase, for o-methylphenyl glycidyl ether by multiple sitedirected mutagenesis on the basis of rational design. Molecular Catalysis. 2019, 476, 110517.

92.     Haijuan Hou, Jinsong Gong, Yuxiu Dong, Jiufu Qin, Heng Li, Hui Li, Zhenming Lu, Xiaomei Zhang, Zhenghong Xu, Jinsong Shi. Phospholipase D Engineering for Improving the Biocatalytic Synthesis of Phosphatidylserine. Bioprocess and Biosystems Engineering. 2019, (4): 1-10. 

93.     Jianrong Wu, Jingbo Zhang, Hongtao Zhang, Minjie Gao, Liming Liu, Xiaobei Zhan. Recycling of cooking oil fume condensate as a substrate for rhamnolipids production of by Pseudomonas aeruginosa WB505. Bioprocess and Biosystem Engineering. 2019, 42(5): 777-784.