柳艺石

邮箱: liuyishi@jiangnan.edu.cn

教育及工作经历

l 2020.12-        江南大学生物工程学院助理研究员

l 2019.07- 2020.12 江南大学生物工程学院博士后

l 2018.09-2019.09 大阪大学微生物病研究所博士后

l 2012.09-2018.06 江南大学生物工程学院 工学博士

l 2008.09-2012.06 江南大学生物工程学院 理学学士

所获荣誉

l 2018.06: 江南大学优秀毕业研究生

l 2017.10: 中心年会最佳报告获得者

l 2015.11: 第7届亚洲糖科学与糖技术国际会议（日本）最佳海报获得者

l 2012.06: 江南大学优秀毕业生

l 2010.10: 江南大学国家奖学金获得者

研究兴趣

l GPI锚定蛋白生物合成调控机制

l 分子细胞生物学

l 生物工程改造哺乳动物细胞用于生成生物医药糖蛋白

l 蛋白质质量控制及细胞稳态

发表文章

[1] Liu Y S, Matabaro E, Gao X D, et al. Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system [J]. J Biosci Bioeng, 2020, DOI:10.1016/j.jbiosc.2020.10.004.

[2] Liu Y S, Fujita M. Mammalian GPI-anchor modifications and the enzymes involved [J]. Biochem Soc Trans, 2020, 48(3): 1129-1138.

[3] Liu Y S, Guo X Y, Hirata T, et al. N-Glycan-dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing [J]. J Cell Biol, 2018, 217(2): 585-599.

[4] Guo X Y, Liu Y S, Gao X D, et al. Calnexin mediates the maturation of GPI-anchors through ER retention [J]. J Biol Chem, 2020, 295(48): 16393-16410.

[5] Wang Y, Maeda Y, Liu Y S, et al. Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation [J]. Nat Commun, 2020, 11(1): 860.

[6] Kitajima T, Xue W, Liu Y S, et al. Construction of green fluorescence protein mutant to monitor STT3B-dependent N-glycosylation [J]. FEBS J, 2018, 285(5): 915-928.

[7] Mutumwinka D, Zhao S B, Liu Y S, et al. PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells [J]. Biosci Biotechnol Biochem, 2018, 82(9): 1497-1507.

[8] Matabaro E, He Z, Liu Y S, et al. Molecular switching system using glycosylphosphatidylinositol to select cells highly expressing recombinant proteins [J]. Sci Rep, 2017, 7(1): 4033.

[9] Rong Y, Nakamura S, Hirata T, et al. Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis [J]. PLoS One, 2015, 10(9): e0138553.