欢迎来到糖化学与生物技术教育部重点实验室
糖药物与生物医用材料研究​室
  2017-05-18  

一、简介

本研究室致力于多糖类生物活性大分子与蛋白质之间相互作用的研究,并围绕(1)糖胺聚糖类药物;(2)多糖-蛋白质医用材料;(3)多糖药物传递系统,在癌症、心脑血管疾病的治疗,以及免疫疗法开展工作。研究室拥有先进的实验室设施和配套的功能实验室,并拥有能满足开展教学与科研工作所需的仪器设备。研究室现有教授1名,副教授3名。近年来,主持或参与包括973、国家自然科学基金、省部级科技项目以及企业委托项目10余项,在国内外发表研究论文90余篇,申请国际/国家发明专利10余项。

介绍

二、研究室成员

教授:陈敬华

副教授:陈荆晓;周娟;邱立朋;许淑琴;张慧杰

秘书:王睿

三、科研成果

文章

1.      Fu H, Teng L, Bai R, Deng C, Lv G, Chen J. Application of acellular intima from porcine thoracic aorta in full-thickness skin wound healing in a rat model. Mater Sci Eng C Mater Biol Appl. 2017, 71: 1135.

2.      Yu L, Xu X, Lv G, Chen J. Chain conformation and rheological behavior of exopolysaccharide from Bacillus mucilaginosus SM-01. Food Hydrocoll. 2017, 65: 165.

3.      Qiu L, Zhu M, Huang Y, Gong K, Chen J. Mechanisms of cellular uptake with hyaluronic acid-octadecylamine micelles as drug delivery nanocarriers. RSC Advances. 2016, 6: 39896.

4.      Yu L, Xu S, Deng C, Li H, Yang Q, Xu Z, Chen J. Preparation and partial structural characterization of the exopolysaccharide from Bacillus mucilaginosus SM-01. Carbohydr Polym. 2016, 146: 217.

5.      Chen J, Cao L, Shi Y, Wang P, Chen J. In situ supramolecular hydrogel based on hyaluronic acid and dextran derivatives as cell scaffold. J Biomed Mater Res A. 2016, 104(9): 2263.

6.      Deng C, Shang J, Fu H, Chen J, Chen J. Mechanism of the immunostimulatory activity by a polysaccharide from Dictyophora indusiata. Int J Biol Macromol. 2016, 91: 752.

7.      Teng L, Fu H, Wang M, Deng C, Chen J. Stimulation of RAW264.7 macrophages by sulfated Escherichia coli K5 capsular polysaccharide in vitro. Mol Med Rep. 2015, 12(4): 5545.

8.      Chen J, Wang M, Tian H, Chen J. Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy. Colloid Surf B: Biointerfaces. 2015, 134: 81.

9.      Teng L, Fu H, Deng C, Chen J, Chen J. Modulating the SDF-1/CXCL12-induced cancer cell growth and adhesion by sulfated K5 polysaccharides in vitro. Biomed Pharmacother. 2015, 73: 29.

10.   Deng C, Xu J, Fu H, Chen J, Xu X. Characterization, antioxidant and cytotoxic activity of sulfated derivatives of a water-insoluble polysaccharides from Dictyophora indusiata. Mol Med Rep. 2015, 11: 2991.

11.   Teng L, Fu H, Wang M, Deng C, Song Z, Chen J. Immunomodulatory activity of heparan sulfate mimetics from Escherichia coli K5 capsular polysaccharide in vitro. Carbohydr Polym. 2015, 115: 643.

12.   Zhao S, Wang Z, Chen J, Chen J. Preparation of heparan sulfate-like polysaccharide and application in stem cell chondrogenic differentiation. Carbohydr Res. 2015, 401: 32.

13.   Gong K, Wang H, Ren X, Wang Y, Chen J. β-Cyclodextrin-butane sulfonic acid: an efficient and reusable catalyst for the multicomponent synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions. Green Chem. 2015, 17: 3141.

14.   Fu H, Deng C, Teng L, Yu L, Su T, Xu X, Chen J, Yang C. Immunomodulatory Activities on RAW 264.7 Macrophages of a Polysaccharide from Veiled Lady Mushroom, Dictyophora indusiata (Higher Basidiomycetes). Int J Med Mushrooms. 2015, 17(2): 151.

15.   Chen J, Liu W, Zhang M, Chen J. Heparosan based negatively charged nanocarrier for rapid intracellular drug delivery. Int J Pharma. 2014, 473(1-2): 493.

16.   Chen J, Zhang M, Liu W, Lu G, Chen J. Construction of serum resistant micelles based on heparosan for targeted cancer therapy. Carbohydr Polym. 2014, 110: 135.

17.   Chen J, Liang Y, Liu W, Huang J, Chen J. Fabrication of doxorubicin and heparin co-loaded microcapsules for synergistic cancer therapy. Int J Biol Macromol. 2014, 69: 554-560.

18.   Cheng Y, Ma L, Deng C, Xu Z, Chen J. Effect of PEG-mediated pore forming on Ca-alginate immobilization of nitrilase-producing bacteria Pseudomonas putida XY4. Bioprocess Biosyst Eng. 2014, 37: 1653.

19.   Cheng Y, Lu J, Liu S, Zhao P, Lu G, Chen J. The preparation, characterization and evaluation of regenerated cellulose/collagen composite hydrogel films. Carbohydr Polym. 2014, 107: 57.

 

专利

1.     Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues. US2009035787, 2009.

2.     Enzymatic synthesis of sulfated polysaccharides. WO2006124801, 2006.

3.     Purified and isolated heparan sulfate 3-O- sulfotransferase isoform 5 nucleic acids and therapeutic and screening methods using SAME isoform 5 nucleic acids and therapeutic and screening methods using SAME. WO2004005475, 2004.

4.     一种制备肝素修饰的金纳米粒子的方法. ZL200910024843.4, 2013

5.     一种具有自抗炎功能的胶原基海绵伤口敷料的制备方法. ZL201310123232.1

 

四、科研成果(省部级以上科研及人才项目)

国家自然科学基金6项;教育部新世纪优秀人才支持计划1项,教育部博士点基金1项;江苏省自然科学基金2项;江苏省产学研研究项目1项;

 

技术支持:信息化建设与管理中心
校内备案号:JW备170140

地址:江苏省无锡市蠡湖大道1800号
邮编:214122
联系电话:0510-85912032
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