欢迎来到糖化学与生物技术教育部重点实验室
糖化学与糖药物工程研究室
  2015-08-05  

组长简介
课题组长:吴志猛
电 话: 0510-85197582
Email: zwu@jiangnan.edu.cn


    教育与工作经历:
江苏省“特聘教授”(2014)江南大学生物工程学院 教授 教授博士生导师 (2013至今)
新西兰皇家科学院工业研究院 研究科学家(2011-2013)
美国Wayne State University 化学系 博士后 (2008-2011)
美国Karmanos Cancer Institute 博士后 (2005-2008)
浙江大学 博士(2002-2005)


    在研科研项目:
1:国家自然科学基金 糖基化复杂壁磷壁酸的全合成及其免疫活性研究(21472070,2015.1-2018.12)
2:江苏省特聘教授 糖类药物化学(2015.1-2017.12)
3:江苏省”双创计划“创新团队(2015.1-2017.12)
4:江苏省“六大人才高峰“项目
5:北京大学天然药物及仿生药物国家重点实验室开放课题


    学术兼职:
受邀作为Chemical Communications, Journal of organic chemistry, Journal of Combinatorial chemistry, Organic & Biomolecular Chemistry, European Journal of Organic Chemistry, Current Organic Synthesis, European Journal of Medicinal Chemistry, Chemistry Letter, Australian journal of chemistry, Bioorganic & Medicinal Chemistry, Carbohydrate Research等期刊的审稿人


    主要研究内容、目标及进展
多年来一直从事糖化学与药物化学交叉的研究工作, 研究领域涉及抗病毒药物研发,复杂寡糖的全合成以及发展化学酶法合成糖肽和糖蛋白等。团队成员将致力于以糖化学为基础的创新糖类药物研究为主线,利用糖的化学性质和生物学功能,设计和合成单糖,寡糖,多糖,糖肽以及糖缀化合物;开展糖类药物先导化合物的合成方法学研究并研究其构效关系;重点研究糖类化合物在抗病毒(HBV, HCV,HIV),癌症疫苗以及抗生素等领域的应用和开发。


    研究队伍
课题组成员:
邹亮华 副教授、博士
赵鑫锐 博士
在读博、硕士研究生:
2014级博士研究生:陈孝中
2014级硕士研究生:洪皓飞、丁文章、朱涛、刘少中
本科毕业设计:
2012级本科生 王珣
本课题组期待每一位对我们课题感兴趣的高年级本科生,硕博士生和博士后的加盟;有意者请与我(生工A307室)联系。

代表性文章著作及专利
1. Z. Wu, X. Guo, J. Gao, Z. Guo. Sortase A-mediated chemoenzymatic synthesis of complex glycosylphosphatidylinositol-anchored protein
Chem. Commun., 2013, 49, 11689.(IF:6.38)
2. Z. Wu, X. Guo, G. Guo, Z. Guo. Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogues
Org. Lett., 2013, 15, 5906. (IF: 6.14)
3. X. Guo, Z.Wu(并列第一), Z.Guo. New Method for Site-Specific Modification of Liposomes with Proteins Using Sortase A-Mediated Transpeptidation
Bioconjugate Chem., 2012, 23, 650. (IF: 4.58)
4. Z. Wu, Z. Guo. Sortase-Mediated Transpeptidation for Site-Specific Modification of Peptides, Glycopeptides, and Proteins (Review Article)
J. Carbohydr. Chem.2012, 31, 48
5. Z. Wu, X. Guo, Z. Guo. Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides
Chem. Commun., 2011, 47, 9218.(IF:5.504)
6. Z. Wu, X. Guo, Z. Guo. Chemoenzymatic Synthesis of Glycosylphosphatidylinositol-Anchored Glycopeptide
Chem. Comm., 2010, 46, 5773. (IF: 5.504)
7. Z. Wu, X. Guo, Q. Wang, B. M. Swarts, Z. Guo. Sortase A-Catalyzed Transpeptidation of Glycosylphosphatidylinositol Derivatives for Chemoenzymatic Synthesis of GPI-Anchored Proteins
J. Am. Chem. Soc. 2010, 132, 1567. (IF:8.58)
8. Z. Wu, J. C. Drach, M. N. Prichard, M. Yanachkova, I. Yanachkov, T. L. Bowlin, J. Zemlicka. L-Valine Ester of Cyclopropavir – a New Antiviral Prodrug
Antiviral Chemistry and Chemotherapy, 2009, 20, 37.
9. Z. Wu, S. Zhou, J. Zemlicka. Stereoselective approach to the Z-isomers of methylenecyclopropane analogues of nucleosides: A new synthesis of anitiviral synguanol
Nucleosides, Nucleotides & Nucleic Acids, 2009, 28, 165.
10. Z. Wu, X. Huang. The Mn(OAc)3-mediated Oxidative Free Radical Reaction of Allenes with Malonic Acid Ester: A Novel and Efficient Method for the Synthesis of Methyl 4-Oxoalk-2-enoates or Butenolides .
Synthesis, 2006, 45.
11. F. Sa, Z. Wu, X. Huang. Highly regio- and stereoselective synthesis of beta-phenyl-chalcogenyl allyl sulfones by hydrochalcogenation reaction of 1,2-allenyl sulfones
Synthetic Communications, 2006, 36, 2603.
12. Z. Wu, R. Shen, L, Wu, X. Huang. A Novel and Efficient Methods to Synthesis of β-organoseleno subtituted Allyllic Sulfoxides
Chinese chemical Letters, 2005, 16, 1333.
13. Z. Wu, R. Shen, L. Ren, X. Huang. Efficient Synthesis of β-Organochalcogenyl Allyl Sulfoxides via Regioselectively Hydrochalcogenation Reaction of 1,2-Allenyl Sulfoxides.
Synthesis, 2005, 2171
14. Z. Wu, X. Huang. Regioselectively Hydrochalcogenation Reaction of 1,2-Allenyl Phosphine Oxides. A Novel Synthesis of β-Organochalcogenyl Allyl Phosphine Oxides.
Synlett, 2005, 526
15. X. Huang, Z. Wu. Cis-Carbocupration of Acetylenic phosphine Oxides and Its Application in the Stereoselective Synthesis of Polysunstituted Vinyl phosphine Oxides.
Synthesis, 2004, 244

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