欢迎来到糖化学与生物技术教育部重点实验室
蛋白质计算设计研究室
  2015-09-01  

   

    组长简介

    课题组长:许菲教授,博士生导师

    人才称号:青年千人

    E-mail:feixu@jiangnan.edu.cn

    办公电话:0510-85197571

     

    研究方向:结合计算设计和实验验证获得一定性质与功能的生物大分子

    (1)设计纤维蛋白生物材料

    (2)研究纤维蛋白分子柔性

    (3)改造工业酶制剂

     

    教育经历

    罗格斯即新泽西州立大学 (Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA)

    2000-2007年,博士(主修):生物化学/计算生物学。

    2003-2006年,硕士(辅修):食品化学。

    1996-2000年,学士,武汉大学,生物学基地班。

    工作经历

    2014年至今:江南大学,生物工程学院,教授,博士导师

    2007-2014年:博士后助理研究员,罗格斯大学,生物技术及医药中心

    2004-2007年:研究生助理,罗格斯大学,化学及生物化学系

    2001-2004年:普通化学及有机化学实验助教,罗格斯大学,化学及生物化学系

    获奖与荣誉

    2015年:中组部第十一批青年计划支持

     

    研究队伍

    姓名:杨海泉

    职称:副教授

    研究领域:酶工程与技术、发酵工程

    E-mail:haiquanyang@jiangnan.edu.cn

     

    姓名:郑虹宁

    职称:副教授

    研究领域:生物材料制备

    E-mail:hongningzheng@jiangnan.edu.cn

     

    姓名:宁璐璐博士后

    研究领域:生物信息学

    E-mail:ningll@jiangnan.edu.cn

     

    学术论文及综述

    [1]. Fei Xu, Khan, I. J., McGuinness, K., Parmar, A. S., Silva, T., Murthy, S., Nanda, V., Self-assembly of left and right-handed molecular screws, Journal of American Chemical Society, 2013, 135: 18762-18765

    [2].Xu, Fei, Li, J., Jain, V., Tu, R., Huang, Q., Nanda, V., Compositionally Controlled Collagen Peptide Self-Assembly and Fiber Morphology, Journal of American Chemical Society, 2012, 134(1):47-50

    [3].Xu, Fei, Zahid, S., Silva, T., Nanda, V., Computational Design of a Collagen A:B:C-type Heterotrimer, Journal of American Chemical Society, 2011, 133:15260-15263

    [4]. Fei Xu, Silva, T., Joshi, M., Zahid, S., Nanda, V., Circular Permutation Directs Orthogonal Assembly in Complex Collagen Peptide Mixtures, Journal of Biological Chemistry, 2013, 288:31616-31623

    [5].Xu, Fei, Colasanti, A., Li, Y., Olson, W. K., Long-range effects of histone point mutations on DNA remodeling revealed from computational analyses of SIN-mutant nucleosome structures, Nucleic Acids Research, 2010, 38:6872-82

    [6].Xu, Fei, Zhang, L., Koder, R., and Nanda, V., De novo self-assembling collagen heterotrimers using explicit positive and negative design. Biochemistry. 2010, 49, 2307-2316

    [7].Xu, Fei, and Olson, W. K., DNA architecture, deformability, and nucleosome positioning. Journal of Biomolecular Structure and Dynamics.2010, 27(6), 725-739

    [8]. Parmar, S., Xu, Fei, Pike D. H., Belure, S. V., Hasan, N. F., Drzewiecki, K. E., Shreiber, D. I., and Nanda, V., Metal Stabilization of Collagen and de Novo Designed Mimetic Peptides, Biochemistry. 2015, 54, 4987-4997

    [9]. Sumana, G., Xu, Fei, Nanda, V., Sequence Recombination Improves Target Specificity in a Redesigned Collagen Peptide abc-type Heterotrimer, Proteins: Structure, Function and Bioinformatics, 2013, 81(3): 386-393

    [10]. Grzyb, J., Xu, Fei.,Łuczkowska, R., Nanda, V., Reijersee, E., Lubitz, W., Noy, D., Empirical and computational design of iron-sulfur cluster proteins, Biochimi. Biophys. Acta – Bioenergetics, 2012, 1817: 1256-1262

    [11]. Braun, P., Goldberg, E., Negron, C.,  von Jan, M., Xu, Fei, Nanda, V., Koder, R., and Dror, N., Design Principles for Chlorophyll Binding Sites in Helical Proteins Proteins: Structure, Function, and Bioinformatics, 2011, 79:463-476

    [12]. Grzybe, J., Xu, Fei, Weiner, L., Reigjerse, E., Lubits, W., Nanda, V., Dror, N. De novo design of a non-natural fold for an Iron-sulfur protein: an alpha-helical coiled-coil with a four-iron four-sulfur cluster binding site in its central core. Biochim. Biophys. Acta. 2010, 1797(3):406-413

    [13]. Balasubramanian, S., Xu, Fei, and Olson, W. K., DNA Sequence-directed Organization of Chromation: Structure-based computational analysis of nucleosome-binding sequences. Biophysical Journal, 2009, 96:2245-60

    [14]. Nanda, Vikas, Zahid, Sohail, Xu, Fei, Levine, Daniel, Computational design of intermolecular stability and specificity in protein self-assembly. Methods in Enzymology, 2011, 487:575-593

    [15]. Zhurkin, Victor B., Tolstorukov, Michael Y., Xu, Fei, Colasanti, Andrew V., and Olson, Wilma K., “Sequence-dependent variability of B DNA: an update on bending and curvature,” in DNA conformation and transcription, Takashi Ohyama, Ed., Landes Bioscience/Eurekah.com, Georgetown, TX (2005),

    [16]. Nanda, Vikas, Xu, Fei, Hsieh, Daniel, Chapter 18: Modulation of intrinsic protein properties by computational design - Protein Engineering and Design 2010, CRC Press

     

    应邀讲座

    [1]. Xu, Fei, Protein Folding Concepts and the Application to Computational Design of a Fibrous Protein, Invited Seminar of Chemistry Department, Kean University, Feb 2014, Union, NJ.

    [2]. Xu, Fei, Decoding Collagen - Computational Modeling and Design of Fibrous Proteins, Invited Seminar of Chemistry and Biochemistry Department, Rowan University, Jan 2013, Glassboro, NJ.

    [3]. Xu, Fei, Programmable Self-Assembly of Collagen-like Peptides, Invited Seminar of Chemistry and Biochemistry Department, University of Massachusetts-Dartmouth, June 2012, North Dartmouth, MA.

    [4]. Xu, Fei, Computational Design of a Collagen A:B:C-type Heterotrimer, American Chemical Society National Meeting, August 2011, Denver, CO.

    [5]. Xu, Fei Computationally modeled self-assembly of higher order structure of collagen peptides. Gordon Research Seminar and Conference on Collagen, July 2011, New London, NH.

    [6]. Xu, Fei, Self-Assembly of Higher Order Structures of Collagen peptides, 2nd Annual National Postdoc Appreciation Day Symposium, Rutgers/UMDNJ Post-Doc Association, September, 2010. Piscataway, NJ.

    [7]. Xu, Fei, Self-Assembly of High-order Structure of Collagen peptides, Biological Smart Materials Meeting, The New York Academy of Sciences, April 2010, New York City, NY.

    [8]. Xu, Fei, Optimization of Heterotrimeric Interactions of Collagen, Annual Retreat of Center for Advanced Biotechnology and Medicine, Rutgers University, Cook Campus Center, June, 2008, New Brunswick, NJ.

    [9]. Xu, Fei, Sin Mutations in Histone H3 and H4 Affect the Conformation and Interactions of DNA with Histone H2A and H2B, BIOMAPS Institute for Quantitative Biology Student Seminar, Rutgers University, April, 2006, Piscataway, NJ.

   

   

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